C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01) C07D 495/22 (2006.01)
Patent
CA 2670026
The present invention relates generally to azatricyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
L'invention concerne, de manière générale, des agents pharmaceutiques contenant de l'azatricyclique, et notamment des composés inhibant la métalloprotéase azatricyclique. Cette invention concerne plus particulièrement une nouvelle classe de composés inhibant les MMP-3, MMP-8 et/ou MMP-13 azatricycliques, qui offre une puissance et une sélectivité améliorées par rapport aux inhibiteurs de MMP-13, MMP-8 et MMP-3 actuellement connus.
Bluhm Harald
Chevrier Carine
Deng Hongbo
Gallagher Brian M. Jr.
Gege Christian
Alantos Pharmaceuticals Holding Inc.
Gowling Lafleur Henderson Llp
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