C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C07K 16/16 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2447680
This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgE antibodies and derivatives thereof, which bind allergenic hevein with high affinity and specificity. The present invention also relates to processes for making and engineering such hevein- binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of allergenic hevein in biological and raw material samples, as well as in immunotherapy, enabling blocking of allergenic hevein in allergic patients.
La présente invention concerne une technique du génie portant sur des anticorps. La présente invention concerne plus particulièrement des anticorps IgE humains et des dérivés de ces derniers, fixant l'hevein allergène avec une haute affinité et spécificité. La présente invention concerne également des procédés d'utilisation de ces anticorps et de leurs dérivés dans le domaine immunodiagnostique, pour analyser qualitativement et quantitativement l'hevein allergène dans des prélèvements biologiques et des prélèvements de matière première, ainsi que dans le domaine de l'immunothérapie, pour bloquer l'hevein allergène chez des patients allergiques.
Haahtela Tari
Laukkanen Marja-Leena
Makinen-Kiljunen Soili
Soderlund Hans
Takkinen Kristiina
Mccarthy Tetrault Llp
Valtion Teknillinen Tutkimuskeskus
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