Hex ii tumor-specific promoter and uses thereof in cancer...

Details Hex ii tumor-specific promoter and uses thereof in cancer... Hex ii tumor-specific promoter and uses thereof in cancer...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2266846

The present invention relates to a tumor-specific promoter for use in gene targeted therapy that is differentially regulated in cancer cells, which comprises Hex II promoter. The present invention also relates to a gene construct, which include Hex II promoter in a vector selected from pCAT basic expression vector p.DELTA.ElsplB and a shuttle plasmid, and which optionally includes .beta.-gal or HSV Tk.

Promoteur spécifique des tumeurs destiné à être utilisé dans la thérapie génique, qui est régulé de manière différentielle dans des cellules cancéreuses et qui comporte un promoteur Hex II. La présente invention concerne également un produit de recombinaison génique qui comporte le promoteur Hex II dans un vecteur choisi entre le vecteur p.DELTA.Elsp1B d'expression de base pCAT et un plasmide navette, et qui comporte éventuellement .beta.-gal ou HSV Tk.

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