Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with...

Details Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with... Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with...

A - Human Necessities

61

K

A61K 31/4985 (2006.01) A61P 1/08 (2006.01) A61P 29/00 (2006.01) C07D 221/00 (2006.01) C07D 241/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2539444

The invention relates to hexahydro-pyrido[1,2-a]pyrazine derivatives having interesting neurokinin-NK1 receptor antagonistic activity. The invention also relates to methods for the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient, as well as to the use of these compositions for the treatment of disorders in which neurokinin receptors are involved. The invention relates to compounds represented by the general formula (1) wherein the symbols have the meanings as given in the description.

L'invention se rapporte à des dérivés de hexahydro-pyrido[1,2-a]pyrazine présentant une activité antagoniste contre le récepteur NK1 de neurokinine. Cette invention a aussi trait à des procédés de préparation de ces composés, à des compositions pharmaceutiques contenant une quantité pharmaceutiquement active d'au moins un de ces composés en tant qu'ingrédient actif, ainsi qu'à l'utilisation de ces compositions pour le traitement de troubles dans lesquels les récepteurs de neurokinine sont impliqués. Cette invention porte aussi sur des composés représentés par le formule générale (1) dans laquelle les symboles ont les significations qui figurent dans le descriptif.

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