Hexa-cyclic camptothecin derivatives

Details Hexa-cyclic camptothecin derivatives Hexa-cyclic camptothecin derivatives

C - Chemistry, Metallurgy

07

D

260/246.1, 260/2

C07D 491/14 (2006.01) C07D 471/22 (2006.01) C07D 491/22 (2006.01) C07D 495/22 (2006.01)

Patent

CA 1304370

ABSTRACT OF THE DISCLOSURE The present invention provides a novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: Image (I) The compound is prepared from an aminoketone compound and a pyranoindolizine compound through a Friedlaender reaction. It has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.

569969

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