C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) C07D 495/22 (2006.01)
Patent
CA 2059305
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: (see formula I) The compound is prepared from an aminoketone compound and a pyranoindolizine compound by a condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.
Ejima Akio
Ohsuki Satoru
Terasawa Hirofumi
Uoto Kouichi
Daiichi Pharmaceutical Co. Ltd.
Gowling Lafleur Henderson Llp
Kabushiki Kaisha Yakult Honsha
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