C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/428 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2682494
The present invention is directed to therapeutic agents of the formula (I) which are atypical antipsychotics and which arc useful in the treatment of neurological and psychiatric disorders associated with dopamine D2 and serotonin 5-HT2A neurotransmission dysfunction. wherein; R1 is C1-6alkyl, which is unsubstituted or substituted with 1-6 fluoro, wherein R1 and the hydroxyl group on the ring are attached to the same carbon atom; or a pharmaceutically acceptable salt thereof.
La présente invention porte sur des agents thérapeutiques représentés par la formule (I) qui sont des antipsychotiques atypiques et qui sont utiles dans le traitement de troubles neurologiques et psychiatriques associés à un disfonctionnement de la neurotransmission de la dopamine D2 et de la sérotonine 5-HT2A. dans laquelle; R1 est un alkyle en C1-C6, qui est non substitué ou substitué par 1-6 fluoro, R1 et le groupe hydroxyle sur le cycle étant fixés au même atome de carbone; ou un sel pharmaceutiquement acceptable de ces composés.
Bilodeau Mark T.
Nanda Kausik K.
Trotter Wesley B.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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