Hexahydro-5-imino-1,4-heteroazepine derivatives as...

Details Hexahydro-5-imino-1,4-heteroazepine derivatives as... Hexahydro-5-imino-1,4-heteroazepine derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 281/04 (2006.01) A61K 31/55 (2006.01) C07D 243/06 (2006.01) C07D 267/08 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2234641

Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of gastrointestinal motility and inflammation. These diseases and disorders include hypotension, septic shock, toxic shock syndrome, hemodialysis, IL-2 therapy such as in cancer patients, cachexia, immunosuppression such as in transplant therapy, autoimmune and/or inflammatory indications including sunburn, eczema or psoriasis and respiratory conditions such as bronchitis, asthma, oxidant-induced lung injury and acute respiratory distress (ARDS), glomerulonephritis, restenosis, inflammatory sequelae of viral infections, myocarditis, heart failure, atherosclerosis, osteoarthritis, rheumatoid arthritis, septic arthritis, chronic or inflammatory bowel disease, ulcerative colitis, Crohn's disease, systemic lupus erythematosis (SLE), ocular conditions such as ocular hypertension, retinitis and uveitis, type 1 diabetes, insulin-dependent diabetes mellitus and cystic fibrosis.

L'invention porte sur des composés de formule (I) et leurs sels pharmacocompatibles s'avérant utiles pour le traitement de maladies et affections dues à la synthase de l'oxyde nitrique et notamment de troubles neurodégénératifs, de troubles de la motilité gastro-intestinale et d'inflammations. Ces maladies et affections englobent l'hypotension, le choc septique, le syndrome de choc toxique, l'hémodialyse, le traitement de cancéreux par l'IL-2, la cachexie, l'immuno-suppression accompagnant les thérapies de transplantation, les troubles à caractère auto-immunitaire ou inflammatoire tels que les coups de soleil, l'eczéma ou le psoriasis et les troubles respiratoires tels que la bronchite, l'asthme, les lésions pulmonaires dues à des oxydants et l'emphysème pulmonaire, la glomérulonéphrite, les resténoses, les séquelles inflammatoires d'infections virales, les myocardites, l'insuffisance cardiaque, l'athérosclérose, l'arthrose, la polyarthrite rhumatoïde, l'arthrite aiguë suppurée, les troubles intestinaux chroniques ou inflammatoires, la rectocolite hémorragique, la maladie de Crohn, le lupus érythémateux systémique, des troubles oculaires tels que le glaucome, la rétinite ou l'uvéite, les diabètes de type 1, le diabète sucré insulinodépendant, et la fibrose kystique du pancréas.

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