Hexahydroazepine piperidine and pyrrolidine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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260/323, 260/241

C07D 207/08 (2006.01) C07D 211/22 (2006.01) C07D 223/04 (2006.01)

Patent

CA 1105929

- 1 - Abstract The invention concerns a novel process for preparing hexahydroazepine, piperidine and pyrrolidines of formula (I) Image where n is 2,3 or 4, R1 is lower alkyl, R3 is hydrogen, lower alkyl, aryl(lower)alkyl, lower alkenyl or lower alkynyl and R8 is hydrogen or lower alkyl from compounds of formula Image where n and R1 are as above and R is hydrogen, lower alkyl or aryl(lower)alkyl. The products have pharmacological activity, particularly analgesic activity.

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