Hexahydroazepine piperidine and pyrrolidine derivatives

Details Hexahydroazepine piperidine and pyrrolidine derivatives Hexahydroazepine piperidine and pyrrolidine derivatives

C - Chemistry, Metallurgy

07

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C07D 207/267 (2006.01) C07D 207/08 (2006.01) C07D 207/26 (2006.01) C07D 211/22 (2006.01) C07D 211/76 (2006.01) C07D 223/04 (2006.01) C07D 223/10 (2006.01)

Patent

CA 1113465

Abstract The invention concerns novel 2-oxo-hexahydro- azepine, -piperidine and -pyrrolidine derivatives of formula (I) and their aromatised derivatives of formula (II) Image Image (I) (II) where n is 2, 3 or 4, R is hydrogen, lower alkyl or aryl(lower)alkyl, R2 is hydrogen, lower alkyl or aryl(lower)alkyl and R3 is hydrogen, lower alkyl, aryl(lower)alkyl, lower alkenyl or lower alkynyl. The compounds are useful as intermediates for preparing 3,3-disubstituted -hexahydroazepine, -piperidine and -pyrrolidine compounds having pharmacological activity, particularly analgesic activity.

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