Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors...

Details Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors... Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 243/08 (2006.01) A61K 31/551 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2533893

The present invention is directed to hexahydrodiazepinone compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.

L'invention concerne des composés hexahydrodiazépines qui sont des inhibiteurs de l'enzyme dipeptidyl peptidase IV (inhibiteurs de DPP-IV) et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles l'enzyme dipeptidyl peptidase-IV est impliquée, telles que le diabète et notamment le diabète du type 2. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur leur utilisation dans la prévention ou le traitement de maladies dans lesquelles l'enzyme dipeptidyl peptidase IV est impliquée.

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