C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/16 (2006.01) A61K 31/435 (2006.01) A61K 51/00 (2006.01)
Patent
CA 2279293
Hexahydroindenopyridine compounds having formula (I) and relative stereochemistry where R1 is C1-6 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method or inhibiting spermatogenesis in mammals.
L'invention concerne des composés d'hexahydroindénopyridine présentant la structure stéréochimique relative de formule (I), dans laquelle R<1> représente alkyle C1-6; R<2> représente hydrogène ou alkyle C1-6; R<3> représente carboxyle ou un groupe métabolisé en un groupe carboxyle dans des conditions physiologiques mammaliennes; R<4> représente halogène. Des mélanges dudit composé et ses sels d'addition d'acide présentent une forte activité antispermatogène et sont utiles pour inhiber la spermatogenèse chez les mammifères.
Cook C. Edgar
Fail Patricia A.
Jump Joseph M.
Lee Yue-Wei
Stephens John R.
Research Triangle Institute
Robic
LandOfFree
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