Hexahydronaphth (1,2-b) -1,4 -oxazines

Details Hexahydronaphth (1,2-b) -1,4 -oxazines Hexahydronaphth (1,2-b) -1,4 -oxazines

C - Chemistry, Metallurgy

07

D

260/244.8

C07D 265/34 (2006.01) C07D 498/04 (2006.01)

Patent

CA 1204745

TITLE OF THE INVENTION Hexahydronaphth[1,2-b]-1,4-Oxazines ABSTRACT OF THE DISCLOSURE Hexahydronaphth[1,2-b]-1,4-oxazines have dopaminergic activity and display .alpha.2-adrenergic receptor antagonism. They are useful in the treatment of parkinsonism, depression and hypertension. An important method of preparation is by ring closure of the appropriate 2-chloroacetamido- tetrahydronaphthaIen-1-ol and reduction of the resulting cyclic amide carbonyl group.

415084

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