Hexahydronaphthalene ester derivatives, their preparation...

Details Hexahydronaphthalene ester derivatives, their preparation... Hexahydronaphthalene ester derivatives, their preparation...

C - Chemistry, Metallurgy

12

P

C12P 17/06 (2006.01) A61K 31/00 (2006.01) C07C 69/712 (2006.01) C07C 69/736 (2006.01) C07C 205/37 (2006.01) C07C 255/54 (2006.01) C07C 309/63 (2006.01) C07D 309/30 (2006.01) C07D 317/64 (2006.01) C07F 7/18 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2114450

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) [wherein R1 represents a group of formula (II) or (III): Image (II) (III) R2 is hydrogen or a group of formula -OR3; R3, R3a and R3b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arylsulfonyl; R4 is hydrogen or a carboxy- protecting group; R5 is alkyl, alkenyl, alkynyl, aryl, aralkyl or a fused polycycle; and W is alkylene] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

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