Hexahydropyrrolo¬2,3-b|indole carbamates, -ureas, -amides...

Details Hexahydropyrrolo¬2,3-b|indole carbamates, -ureas, -amides... Hexahydropyrrolo¬2,3-b|indole carbamates, -ureas, -amides...

C - Chemistry, Metallurgy

07

D

167/231, 167/240

C07D 487/04 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2035397

Hexahydropyrrolo[2,3-b]indole Carbamates,-Ureas,-Amides and related compounds, a process for their preparation and their use as medicaments The present invention relates to compounds of the formula I, (see formula I) where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl; Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl; R1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, -1- cycloalkyl, heteroaryl or heteroarylloweralkyl; R2 is hydrogen, loweralkyl or arylloweralkyl; R3 is loweralkyl or arylloweralkyl; R4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl; R5 is hydrogen or loweralkyl; and m is 0 or 1, with the proviso that when m is 0, R1 may also be hydrogen, and a process for their preparation. The compounds of the invention are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

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