Hexameric fusion proteins and uses therefor

Details Hexameric fusion proteins and uses therefor Hexameric fusion proteins and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2257861

A hexameric fusion protein containing a dimeric binding protein provided with a tailpiece from an IgA antibody is described. This fusion protein is useful in therapeutics and vaccines, but is particularly well suited for applications for which the binding protein from which it is derived is unsatisfactory because of low binding affinity or for applications where multivalency is desired. These applications include diagnostics, binding assays and screening assays.

L'invention porte sur une protéine de fusion hexamétrique contenant une protéine fixatrice dimère pourvue d'une queue provenant d'un anticorps IgA. Cette protéine de fusion est utile dans des agents thérapeutiques et dans des vaccins, mais convient particulièrement à des applications dans lesquelles la protéine de fixation dont elle est dérivée n'est pas satisfaisante en raison de sa faible affinité de liaison, ou à des applications pour lesquelles une polyvalence est requise. Ces applications comprennent notamment les diagnostics, les analyses de liaison et les analyses pour le criblage.

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