Hexapeptide

Details Hexapeptide Hexapeptide

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2074967

Abstract of the Disclosure A hexapeptide represented by formula (II): A-B-Pro-C-D-E ... (I) where A represents an L- or D- form of arginine or lysine whose N-terminal amino group is alkylated or acylated, B represents an L- or D- form of argine, lysine, or histidine, Pro represents an L- or D- form of proline, C represents an L- or D- form of tyrosine, tryptophan, or phenylalanine, D represents an L- or D- form of valine, isolencine, or leucine, and E represents an L-or D- form of valine, isolencine, or lencine, one of the hydrogen atoms of the amino group of which may be substituted a C1 to C4 alkyl group, and C-terminal car- boxyl group of which is substituted with -COOR*, -CH2OR, or -CONHR wherein R* represents a C1 to C4 alkyl group, and R represents a hydrogen atom or an C1 to C4 alkyl group. The hexapeptide or a pharmaceutically acceptable salt of the hexapeptide is useful as medical agent such as an anti-edematous agent, an anti-shock agent, an anti-thrombus agent, an anti-arteriosclerotic agent, an anti-allergic agent, a hypotensive agent, a would healing agent, and an anti-inflammatory agent.

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