Hexapeptides with sulphate ester groups

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/595 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2030720

Abstract of the Disclosure. Compounds of the formula I; Image I wherein: M is Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; G is Gly, DAla, Pro, Ala, BAla or Sar; W is Trp, MeTrp, Ala or Nal; X is Met; MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; J is Asp, DAsp, MeAsp, Ala or Asn; Fl is (S)-NH, (R)-NH, (S)-RlN or (R)-R2N; F2 is H, Cl, I, Br, F, NO2, NH2, R3 or OR4; Z is NH2, NHR5 or NR5R6; Rl, R2, R3, R5 and R6 are Cl to 6 alkyl; and R4 is H or Cl to 6 alkyl, and pharmaceutically acceptable salts thereof, are new and useful as pharmaceuticals. In particular they are useful for the treatment of obesity and for stimulating contraction of the gall bladder.

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