C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/595 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2030720
Abstract of the Disclosure. Compounds of the formula I; Image I wherein: M is Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; G is Gly, DAla, Pro, Ala, BAla or Sar; W is Trp, MeTrp, Ala or Nal; X is Met; MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; J is Asp, DAsp, MeAsp, Ala or Asn; Fl is (S)-NH, (R)-NH, (S)-RlN or (R)-R2N; F2 is H, Cl, I, Br, F, NO2, NH2, R3 or OR4; Z is NH2, NHR5 or NR5R6; Rl, R2, R3, R5 and R6 are Cl to 6 alkyl; and R4 is H or Cl to 6 alkyl, and pharmaceutically acceptable salts thereof, are new and useful as pharmaceuticals. In particular they are useful for the treatment of obesity and for stimulating contraction of the gall bladder.
Astra Ab
Borden Ladner Gervais Llp
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