Hexosylceramides as adjuvants and their uses in...

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 47/26 (2006.01) A61P 37/04 (2006.01) C07H 15/04 (2006.01) C07H 15/08 (2006.01)

Patent

CA 2624617

The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

La présente invention concerne de nouveaux adjuvants ainsi que leurs emplois dans des préparations pharmaceutiques, comme des vaccins. En particulier, la présente invention concerne de nouveaux composés pouvant être employés en tant qu'adjuvants pour la vaccination prophylactique et/ou thérapeutique dans le traitement de maladies infectieuses, de maladies inflammatoires, de maladies auto-immunes, de tumeurs, d'allergies ainsi que pour le contrôle de la fertilité au sein de populations humaines ou animales. Les composés peuvent plus particulièrement être employés non seulement en tant qu'adjuvants systémiques, mais également et préférentiellement en tant qu'adjuvants mucosaux. En outre, la présente invention concerne leurs emplois en tant que principes actifs dans des préparations pharmaceutiques.

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