C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/51 (2006.01) A61K 38/18 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2627370
The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction.
L'invention concerne de nouveaux mutants biosynthétiques d'un facteur de croissance, dérivés du GDF-5, lesquels présentent une meilleure activité biologique. L'invention concerne des mutations au niveau des positions 453 et 456 du GDF-5 humain, ainsi que l'utilisation de ces mutants pour la thérapie de maladies associées à une dégénérescence/destruction de tissus.
Kruse Michael
Ploger Frank
Pohl Jens
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung von Pha
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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