High affinity anti-human ige antibodies

Details High affinity anti-human ige antibodies High affinity anti-human ige antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2514840

The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

L'invention concerne des anticorps monoclonaux humains à affinité élevée, notamment des anticorps dirigés contre des déterminants isotypiques de l'immunoglobuline E (IgE), ainsi que des équivalents et des dérivés directs desdits anticorps. Lesdits anticorps se fixent à leur cible respective avec une affinité au moins 100 fois supérieure à l'anticorps parent original. Lesdits anticorps sont utiles pour le diagnostic, la prophylaxie et le traitement de maladies.

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