High affinity anti-tnf-alpha antibodies and method

Details High affinity anti-tnf-alpha antibodies and method High affinity anti-tnf-alpha antibodies and method

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2573259

An isolated human anti-TNF-.alpha. antibody, or antigen-binding portion thereof, containing at least one high-affinity VL or VH antibody chain that is effective, when substituted for the corresponding VL or VH chain of the anti- TNF~-.alpha. scFv antibody having sequence SEQ ID NO: 1, to bind to human TNF- .alpha. with a Koff rate constant that is at least 1.5 fold lower than that of the antibody having SEQ ID NO: 1, when determined under identical conditions.

L'invention concerne un anticorps anti-TNF-.alpha. humain isolé, ou une partie de liaison à l'antigène de ce dernier, contenant au moins une chaîne d'anticorps V<SB>L</SB> ou V<SB>H </SB>à haute affinité qui est efficace, lorsque substituée par la chaîne V<SB>L</SB> ou V<SB>H</SB> correspondante de l'anticorps scFv anti-TNF-.alpha. présentant la séquence SEQ ID NO: 1, pour se lier à la TNF-.alpha. humaine avec une constante cinétique Koff qui est au moins 1,5 fois inférieure à celle de l'anticorps présentant la SEQ ID NO: 1, lorsque déterminée dans des conditions identiques.

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