A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2585043
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.
La présente invention concerne des compositions et des procédés destinés à inhiber la libération d'une cytokine pro-inflammatoire par une cellule de vertébré et à inhiber une cascade de cytokine inflammatoire chez un patient. Les compositions comprennent par exemple des anticorps d'affinité élevée qui se lient spécifiquement à la HMG1 et à des fragments antigéniques de celle-ci. Les anticorps d'affinité élevée de la présente invention et les compositions pharmaceutiques qui les comprennent ont de nombreuses utilisations, par exemple en tant que traitements contre un large éventail de maladies et de troubles inflammatoires tels que la sepsie, la polyarthrite rhumatoïde, la péritonite, la maladie de Crohn, la lésion de reperfusion, la septicémie, le choc endotoxinique, la mucoviscidose, l'endocardite, le psoriasis, le psoriasis arthropathique, l'arthrite, le choc anaphylactique, l'ischémie organique et le rejet des allogreffes. En outre, les anticorps d'affinité élevée de la présente invention peuvent être utilisés dans le diagnostic.
Allan Christian B.
An Ling-Ling
Coyle Anthony
Gao Changshou
Kiener Peter
Medimmune Inc.
Medimmune Llc
Smart & Biggar
LandOfFree
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