High affinity antibodies to human il-6 receptor

Details High affinity antibodies to human il-6 receptor High affinity antibodies to human il-6 receptor

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2652976

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hlL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. The antibody or antibody fragment binds hlL-6R with an affinity at least 2-fold higher relative to its binding to monkey IL-6R.

L'invention concerne un anticorps humain ou un fragment de liaison à l'antigène qui se lie au récepteur de l'IL-6 humaine (hIL-6R) avec un KD d'environ 500 pM ou moins et qui bloque l'activité de l'IL-6 avec une CI50 de 200 pM ou moins. L'anticorps ou le fragment d'anticorps se lie à hIL-6R avec une affinité au moins 2 fois supérieure à sa liaison à l'IL-6R de singe.

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