High affinity dna binding compounds as adjuvants in...

Details High affinity dna binding compounds as adjuvants in... High affinity dna binding compounds as adjuvants in...

A - Human Necessities

61

K

A61K 31/28 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07F 15/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2382820

The invention provides an improved method for the delivery and stabilization of antisense oligodeoxynucleotides (ODNs) to cells. The unmodified ODNs are complexed to a polynuclear platinum compound or to a structural derivative thereof. Complexation neutralizes the charge of the ODN and makes possible its passage into the cell, without the addition of other transfection agents. The invention may be used in the treatment any disease which is amenable to treatment by antisense ODNs. In addition, the invention provides a new method specifically for the treatment of cancer.

L'invention concerne un procédé amélioré de fourniture et de stabilisation d'oligodésoxynucléotides (ODN) antisens Ns) pour des cellules. Les ODN non modifiés sont complexés, de sorte qu'un composé de platine polynucléaire ou un dérivé de ce dernier soit formé. La complexation neutralise la charge de l'ODN et permet son passage dans la cellule sans qu'il soit nécessaire d'ajouter d'autres agents de transfection. Le procédé de l'invention peut être utilisé dans le traitement d'une maladie, quelle qu'elle soit, pouvant faire l'objet d'un traitement par ODN antisens. Par ailleurs, l'invention porte sur un nouveau procédé destiné spécifiquement au traitement du cancer.

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