High affinity fully human monoclonal antibodies to...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07K 7/06 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2605964

The present embodiments are related to high-affinity antibodies directed to IL- 8, methods of making and characterizing such antibodies and uses of such antibodies. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided.

La présente invention concerne des anticorps à affinité élevée d'interleukine-8, des procédés de fabrication et de caractérisation de tels anticorps, et des utilisations de ces anticorps. L'invention concerne également des séquences de polynucléotides isolées codant des molécules d'immunoglobuline à chaîne lourde et à chaîne légère, et des séquences d'acides aminés comportant ces molécules, en particulier des séquences correspondant à des séquences contiguës à chaîne lourde et à chaîne légère englobant les régions de structure (FR) et/ou des régions de détermination de complémentarité (CDR).

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