High affinity hiv t cell receptors

Details High affinity hiv t cell receptors High affinity hiv t cell receptors

C - Chemistry, Metallurgy

07

K

C07K 14/725 (2006.01) A61K 38/17 (2006.01) C12N 15/12 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2602463

The present invention provides TCRs having an affinity (KD) of less than or equal to l~M, and/or an off-rate (koff) of 1x10-3 S-1 or slower, for the SLYNTVATL-HLA- A* 0201 complex PROVIDED THAT when the said TCR is presented by cell and comprises SEQ ID NOs: 1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.

Cette invention concerne des TCR présentant une affinité (KD) inférieure ou égale à l?M et/ou une vitesse de dissociation (koff) de 1x10-3 S-1 ou moins dans le complexe SLYNTVATL-HLA- A* 0201 à condition que lorsque ledit TCR est présenté par lymphocyte et comprend les numéros d'identité séquentielle 1 et 2, la cellule ne soit pas une cellule T native. Ces TCR sont utiles, seuls ou associés à un agent thérapeutique, dans le ciblage de lymphocytes infectés par VIH présentant ce complexe.

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