High affinity human antibodies to human nerve growth factor

Details High affinity human antibodies to human nerve growth factor High affinity human antibodies to human nerve growth factor

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/22 (2006.01)

Patent

CA 2695997

A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, does not cross-react with neurotrophin-3 (NT- 3), and binds human NGF with a KD of about 2 to about 10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

La présente invention concerne un anticorps humain, ou un fragment d'anticorps se liant à l'antigène, qui se lie spécifiquement au facteur humain de croissance nerveuse (NGF) à un KD de 5 pM ou moins, n'a pas de réaction croisée avec la neurotrophine-3 (NT-3), et se lie au NGF humain à un KD d'environ 2 à environ 10 fois supérieur à celui auquel l'anticorps ou le fragment se lie au NGF de rat et de souris. Les anticorps sont utiles pour traiter la douleur, comprenant la douleur inflammatoire, la douleur d'incision post-opératoire, la douleur névralgique, la douleur de fracture, la douleur de fracture ostéoporotique, la névralgie post-herpétique, l'arthrose, la polyarthrite rhumatoïde, la douleur du cancer, la douleur consécutive à un choc, la douleur articulaire de la goutte, ainsi que les maladies, telles que le carcinome hépatocellulaire, le cancer du sein, et la cirrhose du foie.

Affiliated with

Also associated with

Rating

High affinity human antibodies to human nerve growth factor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High affinity human antibodies to human nerve growth factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High affinity human antibodies to human nerve growth factor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1684390