High affinity human antibodies to pcsk9

Details High affinity human antibodies to pcsk9 High affinity human antibodies to pcsk9

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61P 3/06 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2747123

An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.

L'invention porte sur un anticorps humain ou sur un fragment de liaison à un antigène d'un anticorps humain qui se lie et inhibe spécifiquement la proprotéine convertase humaine subtilisine/kexine de type 9 (hPCSK9) qui est caractérisée par l'aptitude à réduire le cholestérol LDL dans le sérum de 40-80 % sur une période de 24, 60 ou 90 jours par rapport aux taux d'avant la dose, avec peu ou pas de réduction du cholestérol HDL dans le sérum et/ou peu ou pas d'effet mesurable sur la fonction du foie, tel que déterminé par des mesures ALT et AST.

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