High affinity humanized anti-cea monoclonal antibodies

Details High affinity humanized anti-cea monoclonal antibodies High affinity humanized anti-cea monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2321947

Novel humanized monoclonal antibodies, fragments or derivatives thereof which specifically bind carcinoembryonic antigen (CEA) are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express CEA as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express CEA.

Cette invention concerne de nouveaux anticorps monoclonaux humanisés ainsi que des fragments ou des dérivés de ces anticorps, lesquels se lient de manière spécifique à l'antigène carcino-embryonnaire (ACE). Cette invention concerne également des procédés de production des ces anticorps et de leurs fragments ou dérivés. Ces anticorps humanisés sont utiles dans le traitement des cancers qui expriment l'ACE, ainsi qu'à des fins diagnostiques comme, par exemple, l'imagerie in vivo de tumeurs ou de cellules cancéreuses qui expriment l'ACE.

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