High affinity humanized anti-tag-72 monoclonal antibodies

Details High affinity humanized anti-tag-72 monoclonal antibodies High affinity humanized anti-tag-72 monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2321932

Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.

Cette invention concerne de nouveaux anticorps monoclonaux humanisés ainsi que des fragments et des dérivés de ces anticorps humanisés, lesquels se lient de manière spécifique au TAG-72. Cette invention concerne également des procédés de production des ces anticorps et de leurs fragments ou dérivés. Ces anticorps humanisés sont utiles dans le traitement des cancers qui expriment le TAG-72, ainsi qu'à des fins diagnostiques comme, par exemple, l'imagerie in vivo de tumeurs ou de cellules cancéreuses qui expriment le TAG-72.

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