High affinity ny-eso t cell receptor

Details High affinity ny-eso t cell receptor High affinity ny-eso t cell receptor

C - Chemistry, Metallurgy

07

K

C07K 14/725 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 38/16 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2566363

The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1~M and/or have an off-rate (koff) of 1x10-3 S-1 or slower.

L'invention a trait à des récepteurs des lymphocytes T (TCR) présentant la propriété de se lier à SLLMWITQC-HLA-A*0201, le peptide SLLMWITQC étant dérivé de la protéine NY-ESO-1, qui est exprimée par toute une gamme de cellules tumorales. Les TCR selon l'invention présentent un K<SB>D</SB> pour ledit complexe peptide-HLA inférieur ou égal à 1 µm et/ou possèdent une vitesse de dissociation (koff) inférieure ou égale à 1x10-3 S-1.

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