High affinity peptide-containing nanoparticles

Details High affinity peptide-containing nanoparticles High affinity peptide-containing nanoparticles

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2406395

The present invention is directed to polymeric nanoparticles functionalized with two or more peptide moieties that possess high affinity to biomolecular targets, the peptide moieties being covalently linked to the nanoparticle polymeric core structure, either directly or via a linker molecule. The invention is further directed to methods of synthesizing these polymeric nanoparticles and to the various applications for which they may be used.

La présente invention concerne des nanoparticules polymères fonctionnalisées par au moins deux fractions de peptides possédant une haute affinité avec des cibles biomoléculaires, les fractions de peptides étant liées par covalence à la structure polymère du noyau des nanoparticules, soit de manière directe soit par une molécule de liaison. L'invention concerne également des procédés de synthèse de ces nanoparticules polymères et les différentes applications pour lesquelles elles peuvent être utilisées.

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