High affinity t cell receptor and use thereof

Details High affinity t cell receptor and use thereof High affinity t cell receptor and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12N 5/0783 (2010.01) A61K 38/17 (2006.01) C07K 14/725 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2743669

The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same, a T cell expressing said TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor- associated antigen.

La présente invention concerne un récepteur de lymphocytes T (TCR) de forte affinité vis-à-vis d'un antigène associé à une tumeur, une molécule d'acide nucléique isolée codant ledit récepteur, un lymphocyte T exprimant ledit TCR et une composition pharmaceutique pouvant être employée dans le traitement de pathologies impliquant des cellules tumorales exprimant ledit antigène associé à une tumeur.

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