High affinity tgf.beta. nucleic acid ligands and inhibitors

Details High affinity tgf.beta. nucleic acid ligands and inhibitors High affinity tgf.beta. nucleic acid ligands and inhibitors

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2380837

Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta.2. Included in the invention are specific RNA ligands to TGF.beta.2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.2 with its receptor.

L'invention concerne des méthodes d'identification et de préparation de ligands à acide nucléique à haute affinité du TGF.beta.2. Sont compris dans l'invention des ligands spécifiques à ARN du TGF.beta.2 identifiés par la méthode SELEX (évolution systématique de ligands par enrichissement exponentiel). L'invention concerne également des ligands à ARN inhibant l'interaction du TGF.beta.2 avec son récepteur.

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