High affinity vascular endothelial growth factor (vegf)...

Details High affinity vascular endothelial growth factor (vegf)... High affinity vascular endothelial growth factor (vegf)...

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380535

Methods are described for the identification and preparation of high-affinity nucleic acid ligands to a VEGF receptor. Included in the invention are specific RNA ligands to a VEGF receptor identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of a VEGF receptor with VEGF.

L'invention concerne des procédés pour identifier et préparer des ligands acide nucléique à forte affinité d'un récepteur VEGF. L'invention concerne également des ligands RNA spécifiques, liés à un récepteur VEGF identifié par la méthode SELEX. Enfin, l'invention concerne des ligands RNA qui empêchent l'interaction d'un récepteur VEGF avec VEGF.

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