High arachidonic acid producing strains of yarrowia lipolytica

Details High arachidonic acid producing strains of yarrowia lipolytica High arachidonic acid producing strains of yarrowia lipolytica

C - Chemistry, Metallurgy

12

P

C12P 7/64 (2006.01) C07H 21/04 (2006.01) C12N 1/18 (2006.01) C12N 9/10 (2006.01) C12N 15/74 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2585178

Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an .omega.-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.

L'invention concerne des souches modifiées de la levure oléagineuse Yarrowia lipolytica pouvant produire plus de 10 % d'acide arachidonique (ARA, un acide gras .omega.-6 polyinsaturé) dans la fraction d'huile totale. Lesdites souches comprennent divers gènes chimériques exprimant des désaturases, des élongases et des acyltransférases hétérologues, et comprennent éventuellement divers gènes inactivés de désaturases et acyltransférases, natifs, destinés à permettre la synthèse et l'accumulation élevée d'ARA. L'invention concerne également des cellules hôtes de production, ainsi que des méthodes de production d'ARA dans lesdites cellules hôtes.

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