A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2700842
The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan- nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provided are methods for altering the diameter of chitosan-nucleic acid polyplexes.
L'invention porte sur des compositions et dispersions de polyplexes chitosane-acide nucléique hautement concentrées, ainsi que sur des procédés pour produire ces compositions et dispersions. Des procédés consistant à mélanger les polyplexes chitosane-acide nucléique comprennent la mixtion en ligne d'une solution de chitosane et d'une solution d'acide nucléique, suivie par la concentration de la dispersion de polyplexes chitosane-acide nucléique, facultativement en présence d'un inhibiteur d'agrégation. L'invention porte en outre sur des procédés permettant de modifier le diamètre des polyplexes chitosane-acide nucléique.
Cheung Anthony
Fleet Carlos
Gao Jun
Hsu Eric C.
Borden Ladner Gervais Llp
Engene Inc.
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