High-concentration lidocaine compositions and methods for...

Details High-concentration lidocaine compositions and methods for... High-concentration lidocaine compositions and methods for...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01)

Patent

CA 2467167

A composition comprising lidocaine-containing liposomes wherein the weight concentration of lidocaine in said composition is greater than 10 %. The composition is prepared by mixing water with an oil phase comprising lidocaine, a C14-C20 alcohol, an alkyl ester of a fatty acid, propylene glycol, and a polyalkyl stearate. The non-aqueous phase may also include a phospholipid such as phosphatidyl choline.

L'invention concerne une composition comprenant des liposomes comprenant de la lidocaïne, dans laquelle la concentration en poids de lidocaïne est supérieure à 10 %. La composition est préparée par un mélange d'eau et d'une phase huileuse comprenant de la lidocaïne, un alcool C<sb>14</sb>-C<sb>20</sb>, un ester alkylique d'acide gras, du propylène glycol, et du polyalkyle stéarate. La phase non aqueuse peut également comprendre un phospholipide, notamment de la phosphatidyle choline.

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