C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2594814
The invention relates to methods for high-throughput screening for compounds that modulate cell growth or promoter activity. The invention provides the use of cell lines with properly regulated promoter-reporter expression, suitable for high-throughput screening. More particularly, the invention relates to such screening to identify compounds that affect cell growth and/or that modulate the effect of cell cycle arrest on the function of a promoter that is responsive to cell cycle inhibition.
La présente invention a trait à des procédés pour le criblage à haut rendement pour des composés de modulation de la croissance cellulaire ou de l'activité de promoteurs. L'invention a trait à l'utilisation de lignées cellulaires avec une expression de promoteur-rapporteur à régulation appropriée, aptes au criblage à haut rendement. Plus particulièrement, l'invention a trait à un tel criblage en vue d'identifier des composés affectant la croissance cellulaire et/ou modulateurs de l'effet d'arrêt de cycle cellulaire sur la fonction d'un promoteur qui est sensible à l'inhibition du cycle cellulaire.
Bey-Dih Chang
Roninson Igor B.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Senex Biotechnology Inc.
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