A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2720849
The present application provides novel compositions comprising posaconazole and a polymer wherein the compo-sition has a glass transition temperature temperature (Tg) of less than about 1100C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng.hr/mL when administered to a patient in a fasted state. The application also describes a novel process for preparing these compositions. The preff erred polymer is HPMCAS. Preferably the composition is an extruded material.
L'invention concerne de nouvelles compositions comprenant du posaconazole et un polymère, ladite composition présentant une température de transition vitreuse (Tg) inférieure à 110 °C environ. L'invention concerne également des compositions comprenant du posaconazole et un polymère présentant une densité apparente supérieure à 0,4 mg/ml environ. En outre, l'invention concerne des compositions comprenant du posaconazole et un polymère, permettant d'obtenir une exposition (AUCtf) d'au moins 10000 ng.hr/ml environ, une fois administrées à un patient à jeun. L'invention concerne encore un nouveau procédé de préparation de telles compositions.
Fang Larry Yun
Harris David
Krishna Gopal
Moton Allen E. Jr.
Prestipino Russell C.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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