C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/64 (2006.01) C07H 21/04 (2006.01) C12N 1/18 (2006.01) C12N 9/10 (2006.01) C12N 15/74 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2584719
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an (.omega.-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
L'invention concerne une souche modifiée de levure oléagineuse, Yarrowia lipolytica, capable de produire une quantité supérieure à 25 % d'acide eicosapentanoïque (EPA, un acide gras ?-3 polyinsaturaté) de la partie totale de l'huile. Lesdites souches comprennent de nombreux gènes exprimant des désaturases hétérologues, des élongases et des acyltransférases, et comprennent éventuellement de nombreuses neutralisations de désaturases et d'acyltransférases d'origine, ce qui permet la synthèse et une accumulation élevée d'EPA. L'invention concerne, en outre, les cellules hôtes de production ainsi que des procédés pour produire du DHA dans les cellules hôtes.
Damude Howard G.
Gillies Peter John
Macool Daniel Joseph
Picataggio Stephen K.
Pollak Dana Walters M.
E.i. Du Pont de Nemours And Company
Torys Llp
LandOfFree
High eicosapentaenoic acid producing strains of yarrowia... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with High eicosapentaenoic acid producing strains of yarrowia..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High eicosapentaenoic acid producing strains of yarrowia... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1677436