C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2503437
High expression locus vectors based, in part, on the ferritin heavy chain locus are disclosed. The vectors include distal 5.prime. flanking sequences and/or proximal 5.prime. regulatory sequences derived from ferritin heavy chain locus. The vectors include a site for insertion of heterologous sequences and proximal 3.prime. regulatory and distal 3.prime. flanking sequences . The proximal 3.prime. regulatory and distal 3.prime. flanking sequences are optionally derived from the ferritin heavy chain locus. Cells transformed with the vectors, and methods of producing heterologous proteins encoded by the vectors, are also disclosed.
L'invention concerne des vecteurs de locus à expression élevée fondés, en partie, sur le locus à chaîne lourde de ferritine. Ce vecteur comprend des séquences flanquantes en 5' distales et/ou des séquences régulatrices en 5' proximales issues du locus à chaîne lourde de ferritine. Ces vecteurs comprennent un site pour l'insertion de séquences hétérologues et des séquences flanquantes régulatrices en 3' proximales et en 3' distales. Les séquences flanquantes régulatrices en 3' proximales et en 3' distales sont facultativement issues du locus à chaîne lourde de ferritine. L'invention concerne aussi des cellules transformées au moyen des vecteurs, et des procédés de production de protéines hétérologues codées par les vecteurs.
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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