High flux hollow fiber membrane

Details High flux hollow fiber membrane High flux hollow fiber membrane

B - Operations, Transporting

01

D

B01D 71/16 (2006.01) A61M 1/16 (2006.01) B01D 63/02 (2006.01) B01D 65/00 (2006.01) B01D 65/02 (2006.01) B01D 67/00 (2006.01) B01D 69/02 (2006.01) B01D 69/08 (2006.01)

Patent

CA 2149418

Semipermeable membranes are disclosed for purifying aqueous biological fluids. The membranes are particularly suitable for purifying extracorporeal blood via hemodialysis. The membranes, preferably configured as hollow fibers, are made from a hy- drophilic polymeric material, preferably cellulose acetate. Features of the membranes include an ultrafiltration coefficient (K uF) of about 15 to about 55 mL/hr/mmHg/m2 (thus termed "high-flux" type membranes), a urea mass transfer coefficient (K oV (urea)) of at least 38 x 10 -3 cm/min, and a ratio of K oV(urea)/K uF of at least 2.5 x 10 -3. Hollow fibers of such membranes suitable for hemodialysis have a lumen diameter of about 175 to about 210 µm and a wall thickness of about 10 to about 35 µm. According to disclosed methods for making the membranes, a melt comprising about 32 to about 40 % w/w cellulose acetate, about 5 to about 10 % w/w glycerine, and about 50 to about 65 % w/w polyethylene glycol is extruded to make hollow fibers; the fibers are cooled, cold-stretched, water-leached, and replasticized using a glycerine solution.

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