High ibuprofen content granulations

Details High ibuprofen content granulations High ibuprofen content granulations

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2045680

A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film with a portion of said binder to form agglomerates, is disclosed. Ibuprofen may be fluidized with a portion of the binder in a fluid bed apparatus and sprayed with an aqueous dispersion of polyvinylpyrrolidone and the remainder of the binder. This granulation may be subsequently blended with additional excipients and, optionally, additional active pharmaceutical ingredients for direct compression into tablets.

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