High level cytokine production with enhanced cell viability

Details High level cytokine production with enhanced cell viability High level cytokine production with enhanced cell viability

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 14/53 (2006.01) C07K 14/54 (2006.01) C07K 14/555 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2383563

The present invention relates to methods for enhancing the produciton of cytokines in cell culture, particularly under conditions of PKR overproduction. The method is based on suppresion of the apoptotic cell death process in cultured human cells in PKR-overproducing cells.

L'invention concerne des procédés permettant de renforcer la production de cytokines dans une culture cellulaire, en particulier dans des conditions de surproduction de PKR. Le procédé s'appuie sur la suppression du processus de mort cellulaire par apoptose au niveau des cellules humaines de culture dans des cellules surproduisant des PKR.

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