High level expression of polypeptide that contains modified...

Details High level expression of polypeptide that contains modified... High level expression of polypeptide that contains modified...

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) C07K 14/02 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2129156

ABSTRACT The present invention relates to methods of producing recombinant molecules including the nucleotide sequence for the structure of the preS1 region of the surface glycoprotein of the hepatitis B virus, and to compositions of the molecules. Compositions of the recombinant molecules may include a promoter and a marker gene. Cloning vectors are used to incorporate the recombinant molecules into hosts. Cells infected with the chimeric vaccinia produce high levels of preS1 protein. Isolation and purification of the preS1-containing protein is facilitated by the use of a recombinant molecule in which the myristylation site has been deleted by a modification of the nucleotide sequence. The purified preS1-containing protein is useful for development of vaccines, diagnostic kits and therapies.

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