High level expression of proteins

Details High level expression of proteins High level expression of proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/16 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2231394

The invention features a synthetic gene encoding a protein normally expressed in a mammalian cell or eukaryotic cell wherein at least one non-preferred or less preferred codon in the natural gene encoding the mammalian protein has been replaced by a preferred codon encoding the same amino acid.

L'invention se rapporte à un gène synthétique codant une protéine normalement exprimée dans une cellule mammifère ou une cellule eucaryotique, au moins un codon non préféré ou moins préféré du gène naturel codant la protéine mammifère ayant été remplacé par un codon préféré codant le même acide aminé.

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