High molecular mass n,o-sulphated heparosans, process for...

Details High molecular mass n,o-sulphated heparosans, process for... High molecular mass n,o-sulphated heparosans, process for...

C - Chemistry, Metallurgy

12

P

C12P 19/26 (2006.01) C08B 37/00 (2006.01) C08B 37/10 (2006.01) A61K 31/725 (1990.01)

Patent

CA 2083576

ABSTRACT HICH MOLECULAR MASS N,O-SULPHATED HEPAROSANS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THEM ELF SANOPI 32-34 rue Marbeuf F-75008 PARIS The subject of the invention is new high molecular mass N,O-sulphated heparosans consisting of chains or of a mixture of chains having a molecular mass of between 1.5 x 104 and 4.0 x 106 D, characterised by a repeating disaccharide structure of formula I: Image (I) in which E represents, in 0 to 80 % of the disaccharide units of the said N,O-sulphated heparosan, an acetyl group and, in the remaining disaccharide units, a sul- phate group and optionally a hydrogen atom, G represents a hydrogen atom and a sulphate group, and the pharmaceu- tically acceptable salts of the said N,O-sulphated heparosans. Medicine. Figure : none

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