High-molecular weight derivatives of camptothecins

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 81/00 (2006.01) A61K 31/4745 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2502870

It is intended to provide water-soluble derivative of camptothecins which are excellent in therapeutic effect and suitable for chemotherapy for cancer. Namely, a water-soluble high-molecular weight derivative of camptothencins being excellent in sustained-release which is obtained by ester-bonding a carboxylic acid group of a polyethylene glycol-polycarboxylic acid polymer to a phenolic hydroxyl group of phenolic camptothencins.

L'invention concerne des dérivés hydrosolubles de camptothécine ayant un excellent effet thérapeutique et appropriés pour la chimiothérapie du cancer. L'invention concerne en particulier un dérivé de camptothécine de haut poids moléculaire, hydrosoluble, d'excellente libération prolongée, obtenu par liaison ester d'un groupe carboxylate d'un polymère d'acide polyéthylèneglycol-polycarboxylique eu groupe hydroxyle phénolique de la camptothécine phénolique.

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